Under the terms of the agreement, Dualitas will deploy its proprietary DualScreen platform to identify novel candidates. Unlike conventional approaches that target predetermined pairs, this engine functionally interrogates the cell surface to uncover synergistic activities. Dualitas is set to receive an immediate $36.5 million payment, with the potential for further development and commercial milestones plus tiered royalties as the programs progress.
In section Releases
Roche Partners with Dualitas in $1 Billion Antibody Discovery Deal
Dualitas Therapeutics has secured a collaboration with Roche to hunt for next-generation bispecific antibodies, leveraging a massive high-throughput screening platform. The deal, valued at up to $1 billion, tasks the South San Francisco startup with exploring over 300,000 unique protein combinations to address stubborn immunology and inflammation conditions.
Roche will assume responsibility for all subsequent preclinical development, manufacturing, and global commercialization efforts. For Dualitas, the partnership serves as a high-profile validation of its proximity biology focus, a field that aims to trigger therapeutic effects impossible for standard monoclonal antibodies. The company continues to advance its own internal pipeline, including candidates targeting rheumatoid arthritis and dermatologic autoimmune diseases, which are expected to enter clinical trials next year.
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