The clinical trial involved 180 adults with obesity who first underwent a 21-week induction phase with weekly subcutaneous injections. During this period, participants achieved weight reductions ranging from 16% to 19%. Following the induction, subjects were randomized into various maintenance schedules to test the drug's efficacy in preventing weight regain. Those transitioned to every-other-week dosing retained 97% of their progress, while those on a monthly regimen maintained up to 90% of their weight loss.
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Viking Therapeutics Reports Success in VK2735 Weight Maintenance Trial
Patients treated with Viking Therapeutics' dual GLP-1/GIP agonist VK2735 maintained up to 97% of their initial weight loss after transitioning to less frequent dosing regimens. The study, which spanned 33 weeks, demonstrated that monthly and every-other-week injections offer a viable pathway for sustained weight management without a plateau in results.
Beyond weight control, the maintenance phase showed a strong safety profile. Gastrointestinal side effects, such as nausea and vomiting, remained comparable to those observed in the placebo group, suggesting that the drug is well-tolerated even under flexible administration schedules. Brian Lian, CEO of Viking, noted that these findings provide clinicians with new strategies to help patients transition from initial weight loss to long-term management. The company now intends to evaluate oral maintenance dosing in the next stage of the study to further diversify treatment options.
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