The treatment showed notable efficacy in a group of patients who had already undergone extensive prior therapy for the disease, which affects the kidney's waste-filtering tubules. Sumanta Pal, a study investigator and vice chair at City of Hope Comprehensive Cancer Center, highlighted the drug's performance in this difficult-to-treat population. Following these results, Xencor plans to push the candidate into late-stage clinical development.
In section Market Quotes
Xencor Shares Surge on Promising Kidney Cancer Trial Results
Xencor stock jumped 33% in premarket trading Monday, hitting $33.56 after the company reported strong antitumor activity for its experimental drug, XmAb819. The clinical data, focused on advanced clear cell renal cell carcinoma, marks a significant milestone for the biopharmaceutical firm’s oncology pipeline and its long-term development strategy.

Chief Executive Bassil Dahiyat stated that the company remains well-capitalized, with a cash runway extending into 2029. This financial stability supports an accelerated pace of research across both oncology and autoimmune disease portfolios. Investors reacted sharply to the news, pushing shares up by nearly 65% for the year to date as of the end of last week.
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